![Figure 2 from p120-Ras GTPase activating protein (RasGAP): a multi-interacting protein in downstream signaling. | Semantic Scholar Figure 2 from p120-Ras GTPase activating protein (RasGAP): a multi-interacting protein in downstream signaling. | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/3d133a950fd03e9801d44de6cc697ea1a1de739a/3-Figure2-1.png)
Figure 2 from p120-Ras GTPase activating protein (RasGAP): a multi-interacting protein in downstream signaling. | Semantic Scholar
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Probing the mutational landscape of regulators of G protein signaling proteins in cancer | Science Signaling
![Model for regulation of the Ras p21 product and for the GTPase-activating protein (GAP) as a downstream effector and regulator of ras activity. Ras is. - ppt download Model for regulation of the Ras p21 product and for the GTPase-activating protein (GAP) as a downstream effector and regulator of ras activity. Ras is. - ppt download](https://slideplayer.com/slide/12793779/77/images/1/Model+for+regulation+of+the+Ras+p21+product+and+for+the+GTPase-activating+protein+%28GAP%29+as+a+downstream+effector+and+regulator+of+ras+activity.+Ras+is+localized+to+the+inner+aspect+of+the+plasma+membrane.+The+alternating+relaxed+%28GDP+bound%29+and+activated+%28GTP+bound%29+states+of+the+p21+Ras+protein+are+shown+in+normal+cells.+Conversion+of+GDP-+to+GTP-bound+forms+is+the+rate-limiting+step.+Binding+of+the+Grb2+adaptor+protein+to+a+specific+tyrosine-phosphorylated+residue+on+an+activated+%28growth+factor+stimulated%29+receptor+tyrosine+kinase+translocates+the+Sos+guanine+nucleotide+exchange+factor+to+the+plasma+membrane%2C+where+it+stimulates+the+exchange+of+GDP+for+GTP+on+Ras.+Activation+of+Ras+alters+its+conformation+and+enables+it+to+interact+with+and+recruit+the+Raf+serine-threonine+kinase+to+the+membrane+where+it+becomes+activated+by+an+unknown+%28not+Ras%29+mechanism.+Activation+of+Raf+activates+the+downstream+MAP+kinase+signaling+pathway+involved+in+the+mitogenic+response.+In+addition%2C+activation+of+Ras+stimulates+changes+in+cell+shape+and+motility+mediated+through+Rho-like+GTPase+proteins+that+are+part+of+the+Ras+superfamily+of+small+GTPase+proteins.+Inactivation+of+Ras+is+in+part+controlled+by+the+intrinsic+intrinsic+Ras+GTPase%2C+catalyzed+by+GTPase-activating+proteins+%28GAP+and+NF1%29.+Oncogenic+p21+Ras+proteins+with+mutations+at+amino+acid+positions+12%2C+13%2C+59%2C+or+61+remain+in+their+active+GTP-bound+states+and+constitutively+activate+downstream+signaling+pathways..jpg)
Model for regulation of the Ras p21 product and for the GTPase-activating protein (GAP) as a downstream effector and regulator of ras activity. Ras is. - ppt download
![Dual specificity of a prokaryotic GTPase-activating protein (GAP) to two small Ras-like GTPases in Myxococcus xanthus. - FEBS J. - X-MOL Dual specificity of a prokaryotic GTPase-activating protein (GAP) to two small Ras-like GTPases in Myxococcus xanthus. - FEBS J. - X-MOL](https://xpic.x-mol.com/20200905%2F10.1111_febs.15513.jpg)